パーフュージョン培養によるリッタースケールのCAR-T細胞製造へのアプローチ

同種CAR-T療法の投与あたりのコストを削減するには、大量生産を可能にするスケーラブルなソリューションが必要です。 

UCLとRepligenの専門家による本ウェビナーでは、自動化細胞ハーベストと無血清・ゼノフリー培地を備えたシングルユース撹拌タンクバイオリアクターにおけるCAR-Tパーフュージョンプロセスのスケールアップを紹介します。同種異種アプリケーション向けにCAR-Tの拡張をシームレスにスケールアップするための戦略に参加して学びましょう。 

 

【主な学習内容】

 

  1. 2 Lシングルユース撹拌タンクバイオリアクターおよびATFパーフュージョン併用によるCAR‑T細胞増殖
  2. CAR‑T細胞拡張におけるゼノフリー培地の利点
  3. 自動化バイオリアクターによるハーベストおよびバッファー交換がCAR‑T細胞品質に与える影響

ザルトリウスの専門家に相談する

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スピーカー紹介

Pierre Springuel

PhD Candidate, University College London

  Pierre Springuel is a PhD candidate in the Department of Biochemical Engineering at University College London. His research focuses on developing and optimizing scalable manufacturing processes to enable large-scale production of CAR-T cell therapies. He specializes in perfusion process intensification and scale-up in stirred-tank bioreactors, and in automating downstream processing.  

 

Earl Pineda

Associate Director of Upstream Field Applications, Repligen Corporation

  Earl Pineda is the associate director of upstream field applications at Repligen. Earl has been in the biotech industry for about 25 years, and has helped hundreds of companies successfully implement XCell® ATF technology globally over the past 14 years.  He has worked at major biotech companies like Amgen, Novartis and Biomarin in process development, MSAT, and technology transfer.   

 

Dr. Qasim Rafiq

Professor of Cell and Gene Therapy Bioprocess Engineering, Vice Dean (Health) in Faculty of Engineering at UCL

  Dr. Qasim Rafiq is Vice Dean for Health in the Faculty of Engineering and a Professor in Bioprocess Engineering at University College London. He is a multidisciplinary engineer focusing on the bioprocessing, automation, and biomanufacturing of cell and gene-based therapies. 

Julia Hengst

Product Manager, Immune Cell Media

  Julia Hengst is Product Manager for Immune Cell Media at Sartorius. She joined the company as an External Collaborations Manager, where she built and led partnerships through scientific collaborations around immune and stem cell therapies. 

She holds a PhD in immunology and has years of experience in product management for biomedical research and cell and gene therapy clinical applications.